Frequency-domain optical diffuse spectroscopy

          FD ODS setup was created to visualize neoplasia of breast tissue and to estimate its size. The breast is fixed between 2 glass plates and scans in transilluminative configuration using source-detector pair. At the source point we switch between 3 sources with different wavelengths (650, 794 and 850 nm). Spectral information is used for determination of tissue components, which is different in normal and cancer tissue.

– wavelengths 684, 794, 850 nm
– tissue thickness up to 80 mm
– amplitude modulation frequency, 140 MHz

          FD ODS setup:

FD DOT device-1

          Scheme of FD ODS:

FD DOT device-2

          An example of the distribution of blood oxygen saturation level (%) in normal breast tissue (А) and in the case of breast cancer (В):

untitled6          Image of normal breast tissue are characterized by homogeneity and absence of inclusions. In breast cancer, optical inhomogeneities are visualized; tumor zone is clearly defined against the normal tissues. Particularly, blood oxygen saturation level was lower in the projection of a tumor nodule. The arrow shows the tumor region.

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1. Orlova A.G., Turchin I.V., Plehanov V.I., Shakhova N.M., Fiks I.I., Kleshnin M.I., Sergeeva E.A., Konuchenko N.Yu., and Kamensky V.A. Frequency-domain diffuse optical tomography with single source-detector pair for breast cancer detection. Laser Physics Letters, 5(4), p. 321–327 (2008).